2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W004945
    3,6-Dioxaoctanedioic acid 23243-68-7 ≥98.0%
    36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    3,6-Dioxaoctanedioic acid
  • HY-108368
    Azido-PEG2-CH2COOH 882518-90-3 99.03%
    Azido-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG2-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-CH2COOH
  • HY-W045598
    Boc-C16-COOH 843666-40-0 99.98%
    Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
    Boc-C16-COOH
  • HY-33615
    Methyl azetidine-3-carboxylate hydrochloride 100202-39-9 99.66%
    Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<
    Methyl azetidine-3-carboxylate hydrochloride
  • HY-69260
    tert-Butyl 4-formylpiperidine-1-carboxylate 137076-22-3 99.54%
    tert-Butyl 4-formylpiperidine-1-carboxylate is the linker of PROTAC BRM/BRG1 degrader-3 (HY-168251).
    tert-Butyl 4-formylpiperidine-1-carboxylate
  • HY-151716
    Halo-DBCO 1808119-16-5 98.00%
    Halo-DBCO is a click chemistry reagent containing dibenzocyclooctyne (DBCO). Halo-DBCO can be used as a ligand to react with HaloTag to form covalent HaloTag ligand couples.
    Halo-DBCO
  • HY-130324
    Azido-PEG7-amine 1333154-77-0
    Azido-PEG7-amine is a non-cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG7-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG7-amine
  • HY-140895
    Biotin-PEG4-amine 663171-32-2 ≥98.0%
    Biotin-PEG4-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG4-amine
  • HY-42569
    Methyl 3-hydroxypropanoate 6149-41-3 99.83%
    Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyl 3-hydroxypropanoate
  • HY-130503
    N-Boc-PEG1-bromide 164332-88-1
    N-Boc-PEG1-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG1-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Boc-PEG1-bromide
  • HY-135820
    m-PEG12-acid 2135793-73-4 99.12%
    m-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG12-acid
  • HY-140208
    2,2-Oxybis(ethylamine) 2752-17-2 99.96%
    22-Oxybis(ethylamine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    2,2-Oxybis(ethylamine)
  • HY-W016735
    Azido-PEG3-alcohol 86520-52-7 98.17%
    Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG3-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-alcohol
  • HY-W005056
    Boc-NH-PEG2-CH2COOH 108466-89-3 99.87%
    Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG2-CH2COOH
  • HY-117009
    Bis-PEG9-NHS ester 1008402-79-6 ≥98.0%
    Bis-PEG9-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG9-NHS ester
  • HY-42149
    NH2-PEG2-C2-Boc 756525-95-8 ≥98.0%
    NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    NH2-PEG2-C2-Boc
  • HY-140914
    Biotin-PEG4-Amide-C6-Azide 1006592-62-6 99.11%
    Biotin-PEG4-Amide-C6-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-Amide-C6-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG4-Amide-C6-Azide
  • HY-43581
    endo-BCN-O-PNB 1263166-91-1 99.25%
    endo-BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-O-PNB is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-O-PNB
  • HY-135804
    NH2-PEG3-C2-Boc 252881-74-6
    NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG3-C2-Boc
  • HY-130184
    Azido-PEG8-NHS ester 1204834-00-3 99.47%
    Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-NHS ester
PROTAC Linkers Isoform Comparison

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