2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W015088
    Amino-PEG3-C2-Amine 929-75-9 99.32%
    Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG3-C2-Amine
  • HY-140274
    DBCO-PEG12-NHS ester 2093934-94-0 ≥99.0%
    DBCO-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG12-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG12-NHS ester
  • HY-140765
    Azido-PEG4-NHS-ester 1807534-82-2
    Azido-PEG4-NHS-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-NHS-ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-NHS-ester
  • HY-W016735
    Azido-PEG3-alcohol 86520-52-7 98.17%
    Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG3-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-alcohol
  • HY-140755
    Aeide-C1-NHS ester 824426-32-6 ≥98.0%
    Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Aeide-C1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Aeide-C1-NHS ester
  • HY-123916
    DBCO-Biotin 1418217-95-4 98.49%
    DBCO-Biotin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-Biotin
  • HY-43581
    endo-BCN-O-PNB 1263166-91-1 99.25%
    endo-BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-O-PNB is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-O-PNB
  • HY-140345A
    L-Homopropargylglycine hydrochloride 942518-19-6 ≥98.0%
    L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor.
    L-Homopropargylglycine hydrochloride
  • HY-140914
    Biotin-PEG4-Amide-C6-Azide 1006592-62-6 99.11%
    Biotin-PEG4-Amide-C6-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-Amide-C6-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG4-Amide-C6-Azide
  • HY-130503
    N-Boc-PEG1-bromide 164332-88-1
    N-Boc-PEG1-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG1-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    N-Boc-PEG1-bromide
  • HY-135804
    NH2-PEG3-C2-Boc 252881-74-6
    NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG3-C2-Boc
  • HY-141106
    m-PEG12-NHS ester 2207596-93-6 ≥98.0%
    m-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG12-NHS ester
  • HY-W045598
    Boc-C16-COOH 843666-40-0 99.98%
    Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
    Boc-C16-COOH
  • HY-140895
    Biotin-PEG4-amine 663171-32-2 ≥98.0%
    Biotin-PEG4-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG4-amine
  • HY-117009
    Bis-PEG9-NHS ester 1008402-79-6 ≥98.0%
    Bis-PEG9-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG9-NHS ester
  • HY-42149
    NH2-PEG2-C2-Boc 756525-95-8 ≥98.0%
    NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    NH2-PEG2-C2-Boc
  • HY-42569
    Methyl 3-hydroxypropanoate 6149-41-3 99.83%
    Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyl 3-hydroxypropanoate
  • HY-W005056
    Boc-NH-PEG2-CH2COOH 108466-89-3 99.87%
    Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG2-CH2COOH
  • HY-126889
    Bis-PEG5-NHS ester 756526-03-1 99.83%
    Bis-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG5-NHS ester
  • HY-33366
    Boc-NH-PEG3-CH2COOH 462100-06-7
    Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Boc-NH-PEG3-CH2COOH
PROTAC Linkers Isoform Comparison

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